ZyMōt™ Multi 850µl Sperm Separation Devices (Box of 10)
First of their kind, and FDA approved, ZyMōt™ ICSI and ZyMōt™ Multi Sperm Separation Devices deliver the best performing sperm for use in ICSI, IUI and IVF procedures.
The selection of healthy sperm is critical to the success of assisted reproduction procedures (ICSI, IUI, IVF). Yet the most commonly used methods of selecting sperm rely on centrifugation, which has been proven to cause DNA damage and decreased motility, two of the most common factors in failed fertilization, increased risk of abnormal embryo development and early loss of pregnancy.
Developed by Dr. Utkan Demirci and his team at the Demirci BAMM Labs at Harvard Medical School/Brigham & Women’s Hospital and Stanford Medicine, ZyMōt devices mimic nature to facilitate the separation and preparation of the best performing sperm for ART procedures, while eliminating the need for time-consuming sample preparation and sperm damaging centrifugation. Even low-quality semen samples have been shown to yield collected samples that demonstrate a high concentration of progressively motile sperm, with normal morphology.
ZyMōt Sperm Separation Devices can be used in nearly any clinical setting and require no sample preparation, no extensive training and fewer steps to complete, with less materials required. Incredibly efficient and scalable, ZyMōt devices can reduce hands-on tech time by as much as 80% when compared to density gradient centrifugation, while making it incredibly easy to collect more of the healthiest and best performing sperm for use in ART procedures.
The ZyMōt Multi devices employ a patented, single-use design that separates the best performing sperm by mimicking the pathway within the female reproductive tract. ZyMōt Multi is available in two processing volumes: 850µl and 3ml:
The ZyMōt Multi (850μl) features an inlet port that communicates with the lower sample chamber. Simply deposit untreated semen into the inlet port and incubate for 30 minutes. During incubation, the healthiest, most motile sperm make their way through a microporous filter and into the upper collection chamber, where they can be easily captured and removed via the outlet port. Once removed, simply discard the ZyMōt Multi (850μl) device.
Separates healthy, normal morphology sperm from compromised sperm present in a semen sample.
Sperm separated in volumes required for ICSI, IUI & IVF procedures.
No sample prep.
No extensive training.
No expensive equipment.
Lower ROS and DNA fragmentation.
Higher chromatin integrity.
Allows for the standardization of sperm separation processes.
Lower DNA Fragmentation
Comparison of DNA FRAGMENTATION between the raw specimen and the semen processed by density gradient centrifugation and by ZyMōt Multi (850µl) devices.
Comparison of MOTILITY between the raw specimen and the semen processed by density gradient centrifugation and by ZyMōt Multi (850µl) devices.
Higher Chromatin Integrity
ZyMōt Multi (850µl) devices “yielded the highest progressively motile spermatozoa characterized by high DNA integrity.”1
– Dr. Gianpiero Palermo, Dr. Alessandra Parrella, et al (Weill Cornell Medicine); 1ESHRE 2017: Selection of Spermatozoa with Higher Chromatin Integrity Through a Microfluidics Device
The DxNow device yielded the highest progressively motile spermatozoa characterized by high DNA integrity. Couples with unexplained infertility and unable to achieve a pregnancy due to a concealed male factor may benefit from microfluidic sperm sorting to improve their reproductive outcomes. (Center for Reproductive Medicine, Weill Cornell Medicine)
The Acibadem IVF clinic of Turkey reported up to a 50% increase in the pregnancy rates in the first clinical trials using the DxNow devices relative to existing clinical methods.
“Our pregnancy rates have risen by 30% and biochemical pregnancy rates have dropped a lot; fertilizations are above 92% or more! That's why I'm very happy with DxNow’s Sperm Separation Devices.” ―Embryologist Dora Sánchez, Procrea Clinic.
How To Use the ZyMōt Multi Sperm Separation Device
We've so far enjoyed the ease of use with the ZyMot slides and obtaining very, very clean highly motile sperm for ICSI. Our only issue initially was that it is not made clear that the sperm wash overlay must spill over in to the second small well, and it does not on it's own due to the surface tension, and so you have to start adding sperm wash there and then move over to the larger well.