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ZyMōt™ Starter Pack (Box of 3 ea. of 3 Devices)

ZyMōt™ Fertility from DxNow, Inc.

Product image 1ZyMōt™ Starter Pack (Box of 3 ea. of 3 Devices)
Product image 2ZyMōt™ Starter Pack (Box of 3 ea. of 3 Devices)
Product image 3ZyMōt™ Starter Pack (Box of 3 ea. of 3 Devices)

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Item: Zymot-Starter-Kit-1
This product is restricted to sale for physicians and IVF clinics.

ZyMōt™ Starter Pack (Box of 3 ea. of 3 Devices)

First of their kind, and FDA approved, ZyMōt™ ICSI and ZyMōt™ Multi Sperm Separation Devices deliver the best performing sperm for use in ICSI, IUI and IVF procedures. 

The selection of healthy sperm is critical to the success of assisted reproduction procedures (ICSI, IUI, IVF). Yet the most commonly used methods of selecting sperm rely on centrifugation, which has been proven to cause DNA damage and decreased motility, two of the most common factors in failed fertilization, increased risk of abnormal embryo development and early loss of pregnancy.

Developed by Dr. Utkan Demirci and his team at the Demirci BAMM Labs at Harvard Medical School/Brigham & Women’s Hospital and Stanford Medicine, ZyMōt devices mimic nature to facilitate the separation and preparation of the best performing sperm for ART procedures, while eliminating the need for time-consuming sample preparation and sperm damaging centrifugation. Even low-quality semen samples have been shown to yield collected samples that demonstrate a high concentration of progressively motile sperm, with normal morphology.

ZyMōt Sperm Separation Devices can be used in nearly any clinical setting and require no sample preparation, no extensive training and fewer steps to complete, with less materials required. Incredibly efficient and scalable, ZyMōt devices can reduce hands-on tech time by as much as 80% when compared to density gradient centrifugation, making it incredibly easy to collect more of the healthiest and best performing sperm for use in ART procedures.

PRODUCT DETAILS:

The ZyMōt Starter Pack is comprised of three each of the three ZyMōt device models: ZyMōt ICSI, ZyMōt Multi (850μl) and ZyMōt Multi (3ml). This combination package provides embryologists, andrologists and other fertility clinic personnel the opportunity to use and evaluate each of the three ZyMōt device models with patient cases before making further commitment to one or more of the ZyMōt device models:

The ZyMōt ICSI has 5 micro channels; each accommodating 2μL of semen. More than one micro channel is available to accommodate multiple separations. Each channel has an inlet port for applying the semen sample and an outlet port for collecting the motile sperm. The ports are connected by a fluid-filled micro channel in which the separating occurs. Untreated semen is added through the inlet port. After a period of time, the separated sperm are collected from the outlet port.

The ZyMōt Multi devices employ a patented, single-use design that separates the best performing sperm by mimicking the pathway within the female reproductive tract. ZyMōt Multi is available in two processing volumes: 850µl and 3ml:

    • The ZyMōt Multi (850μl) features an inlet port that communicates with the lower sample chamber. Simply deposit untreated semen into the inlet port and incubate for 30 minutes. During incubation, the healthiest, most motile sperm make their way through a microporous filter and into the upper collection chamber, where they can be easily captured and removed via the outlet port. Once removed, simply discard the ZyMōt Multi (850μl) device.
    • The ZyMōt Multi (3ml) also features an inlet port that communicates with the lower sample chamber. Simply deposit untreated semen into the inlet port and incubate for 30 minutes. During incubation, the healthiest, most motile sperm make their way through a microporous filter and into the upper collection chamber, where they can be easily captured and removed via the outlet port. Once removed, simply discard the ZyMōt Multi (3ml) device.

Key Features & Benefits:

    • FDA 510(k) clearance. (FDA approval documents)
    • Sterile, single-use devices. 
    • Sperm separation based on motility/performance.
    • Separates healthy, normal morphology sperm from compromised sperm present in a semen sample.
    • Sperm separated in volumes required for ICSI, IUI & IVF procedures.
    • No sample prep.
    • No centrifugation.
    • No extensive training.
    • No expensive equipment.
    • Lower ROS and DNA fragmentation.
    • Higher chromatin integrity.
    • Allows for the standardization of sperm separation processes.

How To Use the ZyMōt Sperm Separation Devices

ZyMōt ICSI

Download Instructions For Use for ZyMōt ICSI [PDF]

ZyMōt Multi (850μl)

Download Instructions For Use for ZyMōt Multi (850µl) [PDF]

ZyMōt Multi (3ml)

Download Instructions For Use for ZyMōt Multi (3ml) [PDF]

Tips, Warnings and Precautions
Caution: Federal law restricts this device to sale by or on the order of a physician.

    • Device should be used only by properly trained operators.
    • Avoid over- or under-filling the device.
    • Do not use if the packaging is damaged.
    • Device is single-use only and should be restricted to a single individual per device. It may not be reused.
    • Practice universal precautions when handling human body fluids.

Learn more about ZyMōt™ Fertility (www.zymotfertility.com).


Zymot News

DxNow Cleared for ZyMot Sperm Separation Devices

The FDA granted 510(k) clearance for DxNow’s ZyMot ICSI and ZyMot Multi, devices intended for preparing motile sperm from semen to be used in infertile couples.

The devices facilitate the separation and preparation of highly-motile sperm with normal morphology to be used in assisted reproductive technology procedures.

The ZyMot devices can be used to prepare sperm for intracytoplasmic sperm injection, intrauterine insemination and in vitro fertilization procedures.

 FDA News - April 4, 2018

Specifications: 

Mfr No. Zymot-Starter-Kit-1  ZyMōt ICSI, ZyMōt Multi (850μl) and ZyMōt Multi (3ml) (3 each)

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